Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Prog Neuropsychopharmacol Biol Psychiatry. 2000 Oct;24(7):1053-67. doi: 10.1016/s0278-5846(00)00129-9.


1. Different animal tests model different anxiety disorders. Thus, the social interaction test is a model of generalised anxiety disorder, plus-maze Trial 1 models elements of panic disorder and Trial 2 in the elevated plus-maze is a model of specific phobia. 2. Studies of the neuroanatomical and neurochemical pathways controlling behaviour in these different tests provides information on the neurobiological mechanisms modulating anxiety disorders. 3. In the social interaction test, nicotine and 8-OH-DPAT had anxiogenic effects when injected into the dorsal hippocampus or the lateral septum. 4. These ligands were without effect on Trial 1 in the plus-maze when injected into the dorsal hippocampus, but had anxiogenic effects when injected into the lateral septum. 5. On Trial 2 in the elevated plus-maze, nicotine had an anxiolytic effect, but 8-OH-DPAT had an anixiogenic effect when injected into the dorsal hippocampus.

Publication types

  • Review

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage
  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
  • Animals
  • Anxiety Disorders / physiopathology*
  • Disease Models, Animal
  • Hippocampus / drug effects*
  • Hippocampus / pathology
  • Maze Learning
  • Nicotine / administration & dosage
  • Nicotine / pharmacology*
  • Rats
  • Septum of Brain / drug effects*
  • Septum of Brain / physiology
  • Serotonin Receptor Agonists / administration & dosage
  • Serotonin Receptor Agonists / pharmacology*


  • Serotonin Receptor Agonists
  • Nicotine
  • 8-Hydroxy-2-(di-n-propylamino)tetralin