Near fatal acute colchicine intoxication in a child. A case report

Eur J Pediatr. 2000 Dec;159(12):895-7. doi: 10.1007/pl00008364.


An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug.

Conclusion: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

Publication types

  • Case Reports

MeSH terms

  • Beverages
  • Child
  • Citrus
  • Colchicine / adverse effects*
  • Colchicine / therapeutic use
  • Familial Mediterranean Fever / drug therapy*
  • Female
  • Gout Suppressants / adverse effects*
  • Gout Suppressants / therapeutic use
  • Humans


  • Gout Suppressants
  • Colchicine