Tubelactomicin A, a novel 16-membered lactone antibiotic, from Nocardia sp. I. Taxonomy, production, isolation and biological properties

J Antibiot (Tokyo). 2000 Oct;53(10):1096-101. doi: 10.7164/antibiotics.53.1096.

Abstract

A novel 16-membered lactone antibiotic named tubelactomicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated MK703-102F1, was identified as a member of Nocardia. Tubelactomicin A was isolated from the culture broth by Diaion HP20 absorption, ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies and centrifugal liquid-liquid partition chromatography (CPC). Tubelactomicin A showed strong activity against acid-fast bacteria including the drug-resistant strains.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Culture Media
  • Drug Resistance, Microbial
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / metabolism
  • Lactones / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium / drug effects
  • Nocardia / classification*
  • Nocardia / growth & development
  • Nocardia / metabolism*

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Lactones
  • tubelactomicin A