Induction of psychogenic nonepileptic seizures without placebo

Neurology. 2000 Dec 26;55(12):1904-5. doi: 10.1212/wnl.55.12.1904.


The diagnosis of psychogenic nonepileptic seizures (PNES) can only be made with EEG-video monitoring. The authors describe a provocative technique without placebo. Patients with a clinical suspicion for PNES underwent an activation procedure using suggestion, hyperventilation, and photic stimulation. Of 19 inductions performed, 16 (84%) were successful in inducing the habitual episode. The authors' technique had a sensitivity comparable to those using placebo (e.g., saline injection), but does not have disadvantages.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Placebos
  • Psychophysiologic Disorders / diagnosis*
  • Seizures / diagnosis*


  • Placebos