Benign conditions associated with raised serum CA-125 concentration

J Surg Oncol. 2000 Dec;75(4):264-5. doi: 10.1002/1096-9098(200012)75:4<264::aid-jso7>;2-q.


A retrospective audit carried out in the Department of Clinical Biochemistry, covering a period of 42 months, showed 19 benign conditions, that gave rise to elevated serum CA-125 concentrations. These included six patients with non-malignant gynaecological disease, six patients with abdominal disorders, and seven patients with lung disease. These observations confirm that false-positive elevations can occur and that care must be taken before attributing an elevated serum CA-125 as an indicator of ovarian malignancy.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • CA-125 Antigen / blood*
  • Female
  • Genital Diseases, Female / immunology*
  • Humans
  • Lung Diseases / immunology*
  • Medical Audit*
  • Middle Aged
  • Ovarian Neoplasms / immunology*
  • Retrospective Studies


  • CA-125 Antigen