Amyloid beta vaccination: reduced plaques and improved cognition

Nat Med. 2001 Jan;7(1):18-9. doi: 10.1038/83929.


Studies in three different transgenic mouse models suggest that the amyloid beta-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid beta-peptide fragment reduces learning and memory impairments in mice, and this approach may eventually be used to prevent and/or treat this disease in people.

MeSH terms

  • Alzheimer Disease / therapy*
  • Amyloid beta-Peptides / immunology*
  • Animals
  • Cognition Disorders / therapy*
  • Disease Models, Animal
  • Mice
  • Mice, Transgenic
  • Neurofibrillary Tangles*
  • Vaccines / administration & dosage*


  • Amyloid beta-Peptides
  • Vaccines