NO vascular control in Duchenne muscular dystrophy

Nat Med. 2001 Jan;7(1):27-9. doi: 10.1038/83309.

Abstract

A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstrictor response and eventual muscle damage.

MeSH terms

  • Humans
  • Muscle, Skeletal / enzymology
  • Muscle, Skeletal / pathology
  • Muscular Dystrophy, Duchenne / physiopathology*
  • Nitric Oxide / physiology*
  • Nitric Oxide Synthase / biosynthesis*
  • Nitric Oxide Synthase Type I
  • Vasoconstriction / physiology*

Substances

  • Nitric Oxide
  • NOS1 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I