Relation between hospital primary angioplasty volume and mortality for patients with acute MI treated with primary angioplasty vs thrombolytic therapy

JAMA. 2000 Dec 27;284(24):3131-8. doi: 10.1001/jama.284.24.3131.


Context: Institutional experience with primary angioplasty has been suggested as a factor in selecting a reperfusion strategy for patients with acute myocardial infarction (AMI). However, no large studies have directly compared outcomes of primary angioplasty vs thrombolytic therapy as a function of institutional experience.

Objective: To compare outcomes among patients with AMI who were treated with primary angioplasty vs thrombolytic therapy at hospitals with different volumes of primary angioplasty.

Design: Retrospective cohort.

Setting: A total of 446 acute care hospitals with 112 classified as low volume (</=16 procedures), 223 as intermediate volume (17-48 procedures), and 111 as high volume (>/=49 procedures) based on their annual primary angioplasty volume.

Patients: A total of 62 299 patients with AMI treated with primary angioplasty or thrombolytic therapy from June 1, 1994, through July 31, 1999.

Main outcome measure: In-hospital mortality.

Results: Mortality was lower among patients who received primary angioplasty compared with those who received thrombolysis at hospitals with intermediate volumes (4.5% vs 5.9%; P<.001) and high volumes (3.4% vs 5.4%; P<.001) of primary angioplasty. At low-volume hospitals, there was no significant difference in mortality between patients treated with primary angioplasty vs those treated with thrombolysis (6.2% vs 5.9%; P =.58). Adjusting for differences in demographic, medical history, clinical presentation, treatment, and hospital characteristics did not significantly alter these findings.

Conclusions: In this study, patients with AMI treated at hospitals with high or intermediate volumes of primary angioplasty had lower mortality with primary angioplasty than with thrombolysis, whereas patients with AMI treated at hospitals with low angioplasty volumes had similar mortality outcomes with primary angioplasty or thrombolysis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / statistics & numerical data*
  • Cardiology Service, Hospital / standards
  • Cardiology Service, Hospital / statistics & numerical data
  • Female
  • Hospital Mortality*
  • Hospitals / standards*
  • Hospitals / statistics & numerical data*
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / mortality*
  • Myocardial Infarction / therapy*
  • Outcome and Process Assessment, Health Care*
  • Retrospective Studies
  • Surgery Department, Hospital / standards
  • Surgery Department, Hospital / statistics & numerical data
  • Thrombolytic Therapy / statistics & numerical data*
  • United States / epidemiology