Actin dynamics: assembly and disassembly of actin networks

Curr Biol. 2000 Dec 14-28;10(24):R891-5. doi: 10.1016/s0960-9822(00)00845-9.


Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Humans
  • Microfilament Proteins / metabolism*
  • Models, Biological
  • Polymers / metabolism
  • Protein Structure, Tertiary*
  • Proteins / genetics
  • Proteins / metabolism*
  • Wiskott-Aldrich Syndrome Protein


  • Actins
  • Microfilament Proteins
  • Polymers
  • Proteins
  • WAS protein, human
  • Wiskott-Aldrich Syndrome Protein