Checkpoints: It Takes More Than Time to Heal Some Wounds

Curr Biol. 2000 Dec 14-28;10(24):R908-11. doi: 10.1016/s0960-9822(00)00849-6.

Abstract

The S-phase DNA damage checkpoint seems to provide a twist on the checkpoint theme. Instead of delaying replication and allowing repair as a consequence, it may activate repair and delay replication as a consequence.

Publication types

  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia / genetics
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Line
  • Checkpoint Kinase 2
  • DNA Damage*
  • DNA Repair / genetics*
  • DNA Repair / physiology
  • DNA Replication / genetics*
  • DNA Replication / physiology
  • DNA-Binding Proteins
  • Endodeoxyribonucleases*
  • Exodeoxyribonucleases*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Models, Biological
  • Nuclear Proteins*
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Saccharomyces cerevisiae Proteins*
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Fungal Proteins
  • Intracellular Signaling Peptides and Proteins
  • NBN protein, human
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • MEC1 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases
  • RAD53 protein, S cerevisiae
  • Endodeoxyribonucleases
  • Exodeoxyribonucleases
  • MRE11 protein, S cerevisiae