Abstract
The S-phase DNA damage checkpoint seems to provide a twist on the checkpoint theme. Instead of delaying replication and allowing repair as a consequence, it may activate repair and delay replication as a consequence.
MeSH terms
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Animals
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Ataxia Telangiectasia / genetics
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Ataxia Telangiectasia Mutated Proteins
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Cell Cycle / physiology*
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Line
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Checkpoint Kinase 2
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DNA Damage*
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DNA Repair / genetics*
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DNA Repair / physiology
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DNA Replication / genetics*
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DNA Replication / physiology
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DNA-Binding Proteins
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Endodeoxyribonucleases*
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Exodeoxyribonucleases*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins
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Models, Biological
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Nuclear Proteins*
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
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Saccharomyces cerevisiae Proteins*
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Tumor Suppressor Proteins
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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Fungal Proteins
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Intracellular Signaling Peptides and Proteins
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NBN protein, human
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins
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Tumor Suppressor Proteins
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Protein Kinases
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Checkpoint Kinase 2
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ATM protein, human
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Ataxia Telangiectasia Mutated Proteins
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MEC1 protein, S cerevisiae
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Protein Serine-Threonine Kinases
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RAD53 protein, S cerevisiae
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Endodeoxyribonucleases
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Exodeoxyribonucleases
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MRE11 protein, S cerevisiae