Regulation of death receptor-mediated apoptosis pathways

Int J Biochem Cell Biol. Nov-Dec 2000;32(11-12):1123-36. doi: 10.1016/s1357-2725(00)00048-0.


Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the cell type, signalling pathways downstream of the death receptors can be modulated by different proteins such as Bcl-2, FLIPs, chaperones and kinases. Deregulation of apoptosis has been associated with diseases as cancer, autoimmunity and AIDS. Therefore, the identification of modulators of apoptosis has several therapeutic implications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Caspases / metabolism
  • Humans
  • Ligands
  • Molecular Chaperones / metabolism
  • Phosphotransferases / metabolism
  • Proteins / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Signal Transduction
  • fas Receptor / metabolism


  • Ligands
  • Molecular Chaperones
  • Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Tumor Necrosis Factor
  • fas Receptor
  • Phosphotransferases
  • Caspases