Positional signalling and specification of digits in chick limb morphogenesis

Nature. 1975 Mar 20;254(5497):199-202. doi: 10.1038/254199a0.


The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero-posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.

MeSH terms

  • Animals
  • Chick Embryo*
  • Ectoderm
  • Morphogenesis*
  • Wings, Animal / embryology*