Porins and lipopolysaccharide induce apoptosis in human spermatozoa

Clin Diagn Lab Immunol. 2001 Jan;8(1):206-8. doi: 10.1128/CDLI.8.1.206-208.2001.

Abstract

Treatment of human spermatozoa with porins or lipopolysaccharide (LPS) increases spontaneous apoptosis in these cells. Porins and LPS were extracted from Salmonella enterica serovar Typhimurium and Pasteurella multocida and were mixed with human spermatozoa for detection of levels of apoptosis.

MeSH terms

  • Apoptosis*
  • Cell Survival / drug effects
  • DNA Fragmentation
  • Humans
  • Lipopolysaccharides / metabolism*
  • Lipopolysaccharides / pharmacology
  • Male
  • Pasteurella multocida
  • Polymyxin B / pharmacology
  • Porins / metabolism*
  • Porins / pharmacology
  • Salmonella typhimurium
  • Spermatozoa / drug effects
  • Spermatozoa / pathology*

Substances

  • Lipopolysaccharides
  • Porins
  • Polymyxin B