Self-administration of two long-acting monoamine transport blockers in rhesus monkeys

Psychopharmacology (Berl). 2000 Nov;152(4):414-21. doi: 10.1007/s002130000554.


Rationale: 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog with high affinity at and selectivity for the dopamine transporter (DAT). 2beta-propanoyl-3beta-(2-naphthyl)-tropane (HD-23), like cocaine, binds with approximately equal affinity to the DAT, the serotonin transporter, and the norepinephrine transporter but has over a 100-fold higher affinity for these monoamine transporters than cocaine. The reinforcing effects of these drugs have not been evaluated in cocaine-na nonhuman primates.

Objective: The primary goal of the present study was to examine the reinforcing effects of PTT and HD-23 in rhesus monkeys before and after a history of intravenous cocaine self-administration.

Methods: Monkeys (n=4) were initially trained to respond under a fixed-ratio 30 schedule of food presentation. When responding was stable, saline, PTT (0.001-0.03 mg/kg per injection), and HD-23 (0.0003-0.0056 mg/kg per injection) were made available for self-administration for least five sessions per dose. Next, a cocaine dose-effect function (0.0003-0.3 mg/kg per injection) was determined and then

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carrier Proteins / antagonists & inhibitors*
  • Cocaine / administration & dosage*
  • Cocaine / analogs & derivatives*
  • Cocaine-Related Disorders / psychology*
  • Dopamine Antagonists / administration & dosage*
  • Dopamine Plasma Membrane Transport Proteins
  • Injections, Intravenous
  • Macaca mulatta
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Nerve Tissue Proteins*
  • Reinforcement, Psychology
  • Self Administration
  • Tropanes / administration & dosage*


  • 2-propanoyl-3-(2-naphthyl)-tropane
  • Carrier Proteins
  • Dopamine Antagonists
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Tropanes
  • WF 11
  • Cocaine