The duration of lag phase of ascorbate-dependent free radical oxidation of endogenous polyenic lipids in rat liver and myocardium considerably increased after oral administration of lacrinat containing licorice Glycyrrhiza glabra root powder for 1 month. Lacrinat markedly decreased the content of lipid peroxides in rat liver. Ex vivo antioxidant effects of lacrinat in rat liver were comparable with those of beta-carotene-containing preparations carinat and carinat CD. Parapharmaceutics containing both licorice Glycyrrhiza glabra root powder and beta-carotene (carinat forte) markedly increased antioxidant activity of the liver.