The causes and consequences of random and non-random X chromosome inactivation in humans

Clin Genet. 2000 Nov;58(5):353-63. doi: 10.1034/j.1399-0004.2000.580504.x.


X chromosome (X) inactivation is a remarkable biological process including the choice and cis-limited inactivation of one X, as well as the stable maintenance of this silencing by epigenetic chromatin alterations. The process results in females generally being mosaic for two populations of cells--one with each parental X active. In this review, we discuss recent advances in our understanding of how inactivation works, as well as the causes and clinical implications of deviations from random inactivation.

Publication types

  • Review

MeSH terms

  • Chromatin / genetics
  • Dosage Compensation, Genetic*
  • Gene Silencing
  • Humans
  • Mosaicism / genetics
  • Trisomy / genetics
  • Twins
  • X Chromosome*


  • Chromatin