Pathologic analysis of the sentinel lymph node

Surg Clin North Am. 2000 Dec;80(6):1695-719. doi: 10.1016/s0039-6109(05)70256-5.


The development of the sentinel lymph node concept has had a revolutionary effect on the way radical cancer surgery is viewed. The selective excision of the sentinel node alone has been proposed as an alternative to complete regional lymphadenectomy. This article addresses the sentinel lymph node hypothesis and the role of pathologic analysis, radiation safety, intraoperative and postoperative assessment, pathologic analysis in prognosis, and polymerase chain reaction-based studies.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Breast Neoplasms / pathology
  • Humans
  • Intraoperative Care / methods
  • Lymph Node Excision
  • Lymphatic Metastasis / pathology*
  • Melanoma / pathology
  • Polymerase Chain Reaction
  • Postoperative Care / methods
  • Predictive Value of Tests
  • Prognosis
  • Radiation Protection
  • Reproducibility of Results
  • Sentinel Lymph Node Biopsy / methods*