Reactivation of viral replication after liver resection in patients infected with hepatitis B virus

Ann Surg. 2001 Jan;233(1):139-45. doi: 10.1097/00000658-200101000-00020.


Objective: To investigate the mechanisms and risk factors underlying postoperative reactivation of hepatitis after liver resection for hepatitis B virus-related hepatocellular carcinoma.

Summary background data: Although risk factors for acute hepatic failure after liver resection have been reported in patients with chronic liver disease, the issue of reactivation of hepatitis B virus replication after liver resection is unresolved.

Methods: Fifty-five patients with hepatocellular carcinoma and hepatitis B surface antigen underwent liver resection. In 25 of these 55 patients, serum levels of hepatitis B virus DNA and the type of hepatitis B virus were determined before and after surgery.

Results: Postoperative hepatitis occurred in 13 of the 55 patients (24%). Reactivation of viral replication occurred after liver resection in 7 of the 25 patients tested, and alanine aminotransferase activity increased in 6 of these 7 patients. High preoperative alanine aminotransferase activity, high levels of hepatitis B virus DNA, presence of wild-type DNA, and detection of hepatitis B core antigen in hepatocytes, all features of the immune clearance phase in the natural course of hepatitis B virus infection with no surgery, were more likely to be found in patients with reactivation than in patients without reactivation.

Conclusions: During the immune clearance phase of hepatitis B virus infection, especially the period of acute exacerbation, changes in serum hepatitis B virus DNA level should be monitored for early warnings of reactivation of viral replication, likely to cause severe postoperative hepatitis and acute hepatic failure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alanine Transaminase / analysis
  • Carcinoma, Hepatocellular / surgery
  • Carcinoma, Hepatocellular / virology
  • DNA, Viral / blood
  • Female
  • Hepatectomy
  • Hepatitis B / immunology*
  • Hepatitis B Antigens / analysis
  • Humans
  • Liver / immunology*
  • Liver Neoplasms / surgery
  • Liver Neoplasms / virology
  • Logistic Models
  • Male
  • Middle Aged
  • Risk Factors
  • Statistics, Nonparametric
  • Virus Replication


  • DNA, Viral
  • Hepatitis B Antigens
  • Alanine Transaminase