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, 291 (5501), 134-7

Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

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Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

S T Davis et al. Science.

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  • Retraction
    ST Davis et al. Science 298 (5602), 2327. PMID 12526115. - Retraction of Publication

Abstract

Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.

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