Systemic inflammatory response with plasma C-reactive protein elevation in disk-related lumbosciatic syndrome

Joint Bone Spine. 2000;67(5):452-5.


Objective: To look for a systemic inflammatory response in patients with disk-related lumbosciatic syndrome by using an ultrasensitive (US) plasma C-reactive protein (CRP) assay, and to determine whether plasma CRP-US levels correlated with clinical and/or laboratory features.

Patients and methods: Plasma CRP was assayed using an enzyme-linked immunosorbent assay (ELISA) (detection limit, 5 microg/L) in patients with sciatica shown by computed tomography to be due to a disk herniation. Levels in 35 patients aged 23 to 64 years were compared to those in age- and sex-matched controls.

Results: Mean CRP-US levels measured by ELISA were significantly higher in the patients than in the controls (1.68 vs 0.74 mg/L; P = 0.002). There was a trend toward higher CRP-US levels in the patients with more severe nerve root symptoms.

Conclusion: The significantly higher plasma CRP-US levels by ELISA in our patients with disk-related lumbosciatic syndrome is consistent with a systemic inflammatory response to the local nerve root impingement.

MeSH terms

  • Acute-Phase Reaction / blood*
  • Acute-Phase Reaction / diagnostic imaging
  • Acute-Phase Reaction / pathology
  • Adult
  • C-Reactive Protein / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Intervertebral Disc Displacement / blood*
  • Intervertebral Disc Displacement / diagnostic imaging
  • Intervertebral Disc Displacement / pathology
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / pathology*
  • Male
  • Middle Aged
  • Radiculopathy / blood
  • Radiculopathy / diagnostic imaging
  • Radiculopathy / pathology
  • Sciatica / blood*
  • Sciatica / diagnostic imaging
  • Sciatica / etiology
  • Tomography, X-Ray Computed


  • C-Reactive Protein