Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events

Neuron. 2000 Nov;28(2):585-94. doi: 10.1016/s0896-6273(00)00135-5.

Abstract

Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Biological Clocks / physiology
  • Electrodes, Implanted
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Interneurons / cytology
  • Interneurons / physiology*
  • Male
  • Pyramidal Cells / cytology
  • Pyramidal Cells / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Reproducibility of Results
  • Signal Processing, Computer-Assisted
  • Wakefulness / physiology