Diagnosis of prostatic intraepithelial neoplasia: Prostate Working Group/consensus report

Scand J Urol Nephrol Suppl. 2000:(205):3-10. doi: 10.1080/003655900750169266.


High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not significantly elevate serum PSA concentration or its derivatives, nor does it induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention. Radiation therapy is also associated with a decreased incidence of PIN.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Biopsy
  • Humans
  • Male
  • Prognosis
  • Prostate / pathology
  • Prostatic Intraepithelial Neoplasia / diagnosis*
  • Prostatic Intraepithelial Neoplasia / pathology
  • Prostatic Intraepithelial Neoplasia / therapy
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy