Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder

J Neural Transm (Vienna). 2000;107(11):1361-6. doi: 10.1007/s007020070023.


The insertion/deletion polymorphism of the gene of angiotensin-converting enzyme (ACE) was investigated in a case-control study including 169 patients with suffering from either bipolar disorder type I or unipolar recurrent major depression (DSM-IV) and 169 healthy controls. No significant association was found with bipolar disorder type I or unipolar recurrent depression and the polymorphism of the ACE gene. A previously reported genetic association (Arinami et al., 1996) was not confirmed by the present study.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • DNA Transposable Elements
  • Female
  • Gene Deletion
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mood Disorders / genetics*
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic*


  • DNA Transposable Elements
  • Peptidyl-Dipeptidase A