Differential changes in islet amyloid polypeptide (amylin) and insulin mRNA expression after high-fat diet-induced insulin resistance in C57BL/6J mice

Metabolism. 2000 Dec;49(12):1518-22. doi: 10.1053/meta.2000.18511.

Abstract

Islet amyloid, derived from islet amyloid polypeptide (IAPP or amylin), frequently occurs in type 2 diabetes. Availability of this peptide for amyloid formation may be enhanced by increased islet expression of IAPP. In the insulin resistant state, euglycemia is maintained by hypersecretion of insulin. Whether

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / genetics*
  • Animals
  • Dietary Fats / administration & dosage*
  • Dietary Fats / pharmacology
  • Glucose / physiology
  • Glucose Tolerance Test
  • In Situ Hybridization
  • Insulin / genetics*
  • Insulin Resistance / physiology*
  • Islet Amyloid Polypeptide
  • Islets of Langerhans / metabolism
  • Mice
  • Mice, Inbred C57BL
  • RNA, Messenger / metabolism*

Substances

  • Amyloid
  • Dietary Fats
  • Insulin
  • Islet Amyloid Polypeptide
  • RNA, Messenger
  • Glucose