Methadone, ciprofloxacin, and adverse drug reactions

Lancet. 2000 Dec 16;356(9247):2069-70. doi: 10.1016/S0140-6736(00)03409-7.

Abstract

Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesics, Opioid / pharmacokinetics*
  • Anti-Infective Agents / adverse effects*
  • Ciprofloxacin / adverse effects*
  • Confusion / chemically induced*
  • Cytochrome P-450 CYP1A2 Inhibitors
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Drug Interactions
  • Female
  • Humans
  • Methadone / pharmacokinetics*
  • Respiratory Insufficiency / chemically induced*
  • Smoking / physiopathology

Substances

  • Analgesics, Opioid
  • Anti-Infective Agents
  • Cytochrome P-450 CYP1A2 Inhibitors
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Ciprofloxacin
  • Methadone