Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation

Endocrinology. 2001 Jan;142(1):487-92. doi: 10.1210/endo.142.1.7883.


White adipose tissue is known to contain the components of the renin-angiotensin system giving rise to angiotensin II (AngII). In vitro, prostacyclin is synthesized from arachidonic acid through the activity of cyclooxygenases 1 and 2 and is released from AngII-stimulated adipocytes. Prostacyclin, in turn, is able to favor adipocyte formation. Based upon in vivo and ex vivo experiments combined to immunocytochemical staining of glycerol-3-phosphate dehydrogenase (GPDH), an indicator of adipocyte formation, it is reported herein that AngII favors the appearance of GPDH-positive cells. In the presence of a cyclooxygenase inhibitor, this adipogenic effect is abolished, whereas that of (carba)prostacyclin, a stable analog of prostacyclin that bypasses this inhibition, appears unaltered. Taken together, these results are in favor of AngII acting as a trophic factor implicated locally in adipose tissue development. It is proposed that AngII enhances the formation of GPDH-expressing cells from preadipocytes in response to prostacyclin released from adipocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / cytology*
  • Adipocytes / drug effects
  • Adipose Tissue / cytology
  • Adipose Tissue / drug effects
  • Adipose Tissue / physiology*
  • Angiotensin II / pharmacology*
  • Animals
  • Cell Differentiation / drug effects
  • Cells, Cultured
  • Epoprostenol / pharmacology
  • Glycerolphosphate Dehydrogenase / deficiency
  • Glycerolphosphate Dehydrogenase / genetics
  • Glycerolphosphate Dehydrogenase / metabolism*
  • Homozygote
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Rats
  • Rats, Wistar


  • Angiotensin II
  • Epoprostenol
  • Glycerolphosphate Dehydrogenase