The relationship between health-related quality of life and frequency of spells in patients with syncope

J Clin Epidemiol. 2000 Dec;53(12):1209-16. doi: 10.1016/s0895-4356(00)00257-2.


Chronic syncope has a wide range of symptom burden, and anecdotal data suggest substantial but variable physical and psychosocial morbidity. We hypothesized that health-related quality of life (HRQL) is impaired in syncope patients and the degree of impairment is proportional to syncope frequency. The EuroQol EQ-5D was completed by 136 patients (79 female and 57 male) with mean age 40 (SD = 17) prior to assessment. HRQL was substantially impaired in syncope patients compared to population norms in all five dimensions of health measured by the EQ-5D. In patients with six or more lifetime syncopal spells there was a significant (P < 0.001) negative relationship between the frequency of spells and overall perception of health, which was not evident in those who had a history of less than six lifetime spells. These relationships were maintained after controlling for comorbid conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Comorbidity
  • Cross-Sectional Studies
  • Female
  • Humans
  • Linear Models
  • Male
  • Quality of Life*
  • Risk Factors
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Syncope / epidemiology
  • Syncope / physiopathology
  • Syncope / psychology*
  • Tilt-Table Test