Stress management - heat shock protein-70 and the regulation of apoptosis

Trends Cell Biol. 2001 Jan;11(1):6-10. doi: 10.1016/s0962-8924(00)01874-2.


Apoptosis, molecularly regulated cell death, can be induced by a range of environmental, physical or chemical stresses, and is characterized by a sequence of precisely regulated events that culminate in the self-destruction of a cell. Fascinating biochemical and genetic parallels exist between the cell death pathways of different animal species. However, an even more highly conserved and evolutionarily ancient cellular response can be engaged as a consequence of stress, which functions to maintain cellular survival. This response is mediated by the heat-shock or stress proteins. This article discusses the functional interactions between the stress response and the apoptotic cell death pathway and how these might impact on determining cellular survival.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Survival
  • HSP70 Heat-Shock Proteins / physiology*
  • Humans


  • HSP70 Heat-Shock Proteins