Cell motility: proline-rich proteins promote protrusions

Trends Cell Biol. 2001 Jan;11(1):38-46. doi: 10.1016/s0962-8924(00)01876-6.


Many proline-rich proteins participate in delivering actin monomers to specific cellular locations where actin-rich membrane protrusions, such as ruffles, filopodia and microspikes, are formed. These protrusions are necessary for cell motility. Actin monomer is usually delivered to the site of polymerization in the form of profilactin - a complex of G-actin with a polyproline-binding protein, profilin. Here, we describe proline-rich proteins involved in regulating actin polymerization and classify them according to their role in recruiting profilin to the membrane.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / physiology*
  • Amino Acid Motifs
  • Cell Movement / physiology*
  • Contractile Proteins*
  • Microfilament Proteins / physiology
  • Peptides / physiology*
  • Profilins
  • Proline*
  • Proline-Rich Protein Domains
  • Proteins / metabolism
  • rho GTP-Binding Proteins / metabolism


  • Actins
  • Contractile Proteins
  • Microfilament Proteins
  • Peptides
  • Profilins
  • Proteins
  • profilactin
  • Proline
  • rho GTP-Binding Proteins