The Spindle Cycle in Budding Yeast

Nat Cell Biol. 2001 Jan;3(1):E23-7. doi: 10.1038/35050663.


The mitotic spindle of the budding yeast Saccharomyces cerevisiae will probably be the first such organelle to be understood in molecular detail. Here we describe the mitotic spindle cycle of budding yeast using electron-microscope-derived structures and dynamic live-cell imaging. Recent work has revealed that many general aspects of mitosis are conserved, making budding yeast an excellent model for the study of mitosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anaphase / physiology
  • Kinetochores / metabolism
  • Kinetochores / ultrastructure
  • Metaphase / physiology
  • Mitosis / physiology*
  • Models, Biological
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Spindle Apparatus / metabolism*
  • Spindle Apparatus / ultrastructure*