The rational clinical examination. Does this patient have strep throat?

JAMA. 2000 Dec 13;284(22):2912-8. doi: 10.1001/jama.284.22.2912.


Context: Sore throat is a common complaint, and identifying patients with group A beta-hemolytic streptococcal pharyngitis (strep throat) is an important task for clinicians. Previous reviews have not systematically reviewed and synthesized the evidence.

Objective: To review the precision and accuracy of the clinical examination in diagnosing strep throat.

Data source: MEDLINE search for articles about diagnosis of strep throat using history-taking and physical examination.

Study selection: Large blinded, prospective studies (having > or =300 patients with sore throat) reporting history and physical examination data and using throat culture as the reference standard were included. Of 917 articles identified by the search, 9 met all inclusion criteria.

Data extraction: Pairs of authors independently reviewed each article and used consensus to resolve discrepancies.

Data synthesis: The most useful findings for evaluating the likelihood of strep throat are presence of tonsillar exudate, pharyngeal exudate, or exposure to strep throat infection in the previous 2 weeks (positive likelihood ratios, 3.4, 2.1, and 1.9, respectively) and the absence of tender anterior cervical nodes, tonsillar enlargement, or exudate (negative likelihood ratios, 0.60, 0.63, and 0.74, respectively). No individual element of history-taking or physical examination is accurate enough by itself to rule in or rule out strep throat. Three validated clinical prediction rules are described for adult and pediatric populations.

Conclusions: While no single element of history-taking or physical examination is sufficiently accurate to exclude or diagnose strep throat, a well-validated clinical prediction rule can be useful and can help physicians make more informed use of rapid antigen tests and throat cultures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Child
  • Decision Making
  • Diagnosis, Differential
  • Humans
  • Medical History Taking
  • Pharyngitis / diagnosis
  • Pharyngitis / microbiology*
  • Physical Examination*
  • Probability
  • Streptococcal Infections / diagnosis*
  • Streptococcal Infections / physiopathology
  • Streptococcus pyogenes* / isolation & purification