Clinical efficacy of pneumococcal vaccination--a prospective study in patients with longstanding emphysema and/or bronchitis

Eur J Med Res. 2000 Dec 29;5(12):537-40.


In a prospective study the clinical effectiveness of pneumococcal vaccination was evaluated over a 12 months period and compared to a respective analysis of respiratory tract infections in the same patient population. Of 65 enrolled patients with severe and longstanding emphysema and/or chronic bronchitis 52 patients completed the study. One year after vaccination with pneumococcal vaccine in its 23-valent form the incidence of bacterial bronchitis or pneumonia averaged 28 %. As compared to a 12 months period prior vaccination the rate of pneumonia but not of bronchitis was significantly reduced.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Bronchitis / microbiology*
  • Chronic Disease
  • Emphysema / microbiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / therapeutic use*
  • Pneumonia, Pneumococcal / prevention & control*
  • Prospective Studies
  • Retrospective Studies
  • Streptococcus pneumoniae*


  • Pneumococcal Vaccines