T-targets: clues to understanding the functions of T-box proteins

Dev Growth Differ. 2001 Feb;43(1):1-11. doi: 10.1046/j.1440-169x.2001.00556.x.


Members of the T-box gene family have been identified in both vertebrates and invertebrates, where they play key roles in the regulation of embryonic development, and particularly in morphogenesis and the assignment of cell fate. T-box proteins act as transcription factors which regulate the expression of downstream effector genes. This review focuses on the identification of T-box target genes and the basis of T-box functional specificity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Fetal Proteins*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Protein Structure, Tertiary
  • T-Box Domain Proteins / chemistry
  • T-Box Domain Proteins / genetics*
  • T-Box Domain Proteins / physiology*
  • Transcription Factors / metabolism
  • Transcriptional Activation


  • Fetal Proteins
  • T-Box Domain Proteins
  • Transcription Factors
  • Brachyury protein