Growth hormone deficiency caused by pituitary stalk interruption in Fanconi's anemia

J Pediatr. 2001 Jan;138(1):129-33. doi: 10.1067/mpd.2001.109200.

Abstract

Fanconi's anemia can be associated with growth retardation. We describe biologic growth hormone deficiency, isolated or associated with thyrotropin abnormality, and pituitary stalk interruption syndrome on magnetic resonance imaging of 5 patients with Fanconi's anemia. Growth hormone treatment produced catch-up growth in all cases. These findings suggest a common genetic origin.

MeSH terms

  • Body Height / drug effects
  • Body Weight / drug effects
  • Child
  • Child, Preschool
  • Fanconi Anemia / blood
  • Fanconi Anemia / complications*
  • Fanconi Anemia / diagnosis
  • Fanconi Anemia / genetics
  • Female
  • Follicle Stimulating Hormone / blood
  • Growth Disorders / blood
  • Growth Disorders / diagnosis
  • Growth Disorders / drug therapy
  • Growth Disorders / etiology*
  • Human Growth Hormone / deficiency*
  • Human Growth Hormone / pharmacology
  • Human Growth Hormone / therapeutic use
  • Humans
  • Hydrocortisone / blood
  • Infant
  • Infant, Newborn
  • Luteinizing Hormone / blood
  • Magnetic Resonance Imaging
  • Male
  • Pituitary Gland / abnormalities*
  • Prolactin / blood
  • Retrospective Studies
  • Thyrotropin / blood
  • Thyroxine / blood
  • Treatment Outcome

Substances

  • Human Growth Hormone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Thyrotropin
  • Thyroxine
  • Hydrocortisone