Hydroxychloroquine-induced seizure in a patient with systemic lupus erythematosus

Rheumatol Int. 2000 Dec;20(1):31-3. doi: 10.1007/s002960000066.


We report on a case of a 17-year-old female with systemic lupus erythematosus (SLE), with a clinical history of complex partial seizure, who developed a tonicoclonic crisis after receiving hydroxychloroquine for 2 weeks at a dosage of 200 mg/day (5 mg/kg). The absence of previous similar episodes and of recurrences after withdrawal of the drug in subsequent months, the short latency after administration and the favourable short-term evolution raised suspicions for a potential role of the drug in the development of the isolated convulsive crisis. It is possible for hydroxychloroquine to be responsible for tonicoclonic seizures in predisposed subjects.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antirheumatic Agents / adverse effects*
  • Contraindications
  • Female
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Seizures / chemically induced*


  • Antirheumatic Agents
  • Hydroxychloroquine