Allogeneic bone marrow transplantation-related transmission of human T lymphotropic virus type I (HTLV-I)

Bone Marrow Transplant. 2000 Dec;26(11):1235-7. doi: 10.1038/sj.bmt.1702698.


We report here the first case report of bone marrow transplantation (BMT)-related transmission of human T lymphotropic virus type-I (HTLV-I). Antibodies against HTLV-I-associated antigens (anti-HTLV-I) were detected in the serum from the BMT recipient 12 days post BMT. IgG against gag core proteins (anti-p19 and anti-p24) appeared earlier than IgM against gag and env proteins (anti-p19, anti-p24 and anti-gp46) during seroconversion. The data presented here differs from blood transfusion-related seroconversion. This phenomenon may be due to the engraftment of anti-HTLV-I producing cells from the donor.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anemia, Aplastic / therapy
  • Bone Marrow Transplantation / adverse effects*
  • Carrier State / virology
  • HTLV-I Antibodies / blood
  • HTLV-I Infections / immunology
  • HTLV-I Infections / transmission*
  • Human T-lymphotropic virus 1*
  • Humans
  • Living Donors
  • Male


  • HTLV-I Antibodies