Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: a case report

Hum Pathol. 2000 Dec;31(12):1527-31. doi: 10.1053/hupa.2000.20411.


A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparent either operatively, microscopically, or on preoperative computed tomographic scans. The neoplasm has not recurred in a 3-year follow-up. In addition to the fact that osteoclastoma complicating PBD is rare, the extraskeletal origin of the tumor is a matter of interest and can be tentatively explained by an unusually powerful systemic stimulus acting on circulating osteoclast precursors. HUM PATHOL 31:1527-1531.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Giant Cell Tumor of Bone / diagnostic imaging
  • Giant Cell Tumor of Bone / etiology
  • Giant Cell Tumor of Bone / pathology*
  • Giant Cell Tumor of Bone / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / etiology
  • Orbital Neoplasms / pathology*
  • Orbital Neoplasms / surgery
  • Osteitis Deformans / complications
  • Osteitis Deformans / diagnostic imaging
  • Osteitis Deformans / pathology*
  • Soft Tissue Neoplasms / diagnostic imaging
  • Soft Tissue Neoplasms / etiology
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / surgery
  • Tomography, X-Ray Computed