Abstract
To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx). MK-801 or dantrolene, but not FK506, suppressed convulsive seizures in EL mice; only MK-801 reduced NOx in the brain. Our results suggested involvement of the N-methyl-D-aspartate receptor-channel complex and intracellular calcium mobilization, but not calcineurin, in the convulsions of EL mice.
MeSH terms
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Animals
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Brain / drug effects
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Brain / metabolism
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Brain / physiopathology
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Brain Chemistry / drug effects
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Calcineurin / metabolism
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Calcium / metabolism
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Dantrolene / administration & dosage*
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Disease Models, Animal
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Dizocilpine Maleate / administration & dosage*
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Dose-Response Relationship, Drug
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Excitatory Amino Acid Antagonists / administration & dosage
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Immunosuppressive Agents / administration & dosage
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Injections, Intraperitoneal
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Mice
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Mice, Inbred Strains
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Muscle Relaxants, Central / administration & dosage
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Nitrates / analysis
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Nitrates / metabolism
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Nitric Oxide / biosynthesis*
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Nitrites / analysis
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Nitrites / metabolism
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Seizures / drug therapy*
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Seizures / metabolism
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Seizures / physiopathology
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Tacrolimus / administration & dosage*
Substances
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Excitatory Amino Acid Antagonists
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Immunosuppressive Agents
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Muscle Relaxants, Central
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Nitrates
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Nitrites
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Receptors, N-Methyl-D-Aspartate
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Nitric Oxide
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Dizocilpine Maleate
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Calcineurin
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Dantrolene
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Calcium
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Tacrolimus