Abstract
In the present study nicotine (0.1 mg/kg, s.c.) increased discharge rate of putative dorsal raphe (DRN) serotonergic neurons of behaving rats during REM sleep (362.61%), without any significant change during waking and non-REM sleep. Since serotonergic DRN neurons gate PGO onset, these results suggest that nicotine-induced suppression of PGO spikes during REM sleep previously reported is achieved through stimulation of dorsal raphe serotonergic cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Action Potentials / drug effects
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Animals
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Electrodes, Implanted
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Electroencephalography / drug effects
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Electromyography
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Injections, Subcutaneous
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Neurons / classification
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Neurons / cytology
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Neurons / drug effects*
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Neurons / metabolism
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Nicotine / administration & dosage*
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Raphe Nuclei / cytology
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Raphe Nuclei / drug effects*
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Raphe Nuclei / metabolism
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Rats
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Rats, Sprague-Dawley
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Serotonin / metabolism*
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Sleep, REM / drug effects*
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Sleep, REM / physiology
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Wakefulness / drug effects