Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology

Trends Cardiovasc Med. 2000 Jan;10(1):19-22. doi: 10.1016/s1050-1738(00)00039-6.


Myocyte enhancer factor-2 (MEF2), transcription factors and mitogen-activated protein kinase (MAPK) p38 are regulators of cardiac development and various pathophysiologic processes. The recent finding that p38 can directly regulate MEF2 transcription factors suggests a novel mechanism for reprogramming cardiac gene expression in response to neuroendocrine and/or stress stimulation. This review weighs the accumulating evidence for a p38 MAPK-MEF2 signal transduction cascade and discusses its role in cardiac myocyte biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomegaly / metabolism
  • DNA-Binding Proteins / metabolism*
  • Heart / physiology*
  • Humans
  • MEF2 Transcription Factors
  • Mitogen-Activated Protein Kinases / metabolism*
  • Myocardium / cytology*
  • Myocardium / metabolism*
  • Myogenic Regulatory Factors
  • Phosphorylation
  • Signal Transduction / physiology
  • Transcription Factors / metabolism*
  • p38 Mitogen-Activated Protein Kinases


  • DNA-Binding Proteins
  • MEF2 Transcription Factors
  • Myogenic Regulatory Factors
  • Transcription Factors
  • Mitogen-Activated Protein Kinases
  • p38 Mitogen-Activated Protein Kinases