Gastric emptying in diabetic gastroparetic dogs: ffects of SK-951,a novel prokinetic agent

Pharmacology. 2001 Jan;62(1):23-28. doi: 10.1159/000056068.

Abstract

We examined whether delayed gastric emptying could be produced by diabetes in dogs. Diabetes was produced by a single injection of streptozotocin (30 mg/kg i.v.), and diabetic hyperglycemia was observed from 2 to 15 months after injection. The plasma acetaminophen concentration, which is an indirect indicator of the gastric emptying rate, was delayed in 2 of 5 diabetic dogs from 15 months after the induction of diabetes. The effects of SK-951, a benzofuran derivative, on delayed gastric emptying were also examined in diabetic gastroparetic dogs in comparison with those of cisapride. SK-951 (1 mg/kg i.v.) significantly enhanced delayed gastric emptying in diabetic dogs, but cisapride (1 mg/kg i.v.) had no effect. In addition, SK-951 increased the plasma glucose levels in a manner correlated with its effect on gastric emptying. The present study suggested that SK-951 may be useful in the treatment of diabetic gastroparesis.

Publication types

  • Comparative Study

MeSH terms

  • Acetaminophen / administration & dosage
  • Acetaminophen / blood
  • Animals
  • Benzofurans / pharmacology*
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Cisapride / pharmacology
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / physiopathology*
  • Dogs
  • Gastric Emptying / drug effects*
  • Gastrointestinal Agents / pharmacology*
  • Gastroparesis / etiology
  • Gastroparesis / prevention & control*
  • Male
  • Time Factors

Substances

  • Benzofurans
  • Blood Glucose
  • Bridged Bicyclo Compounds, Heterocyclic
  • Gastrointestinal Agents
  • SK 951
  • Acetaminophen
  • Cisapride