Nodular fasciitis is a benign, reactive fibroblastic soft tissue tumor. Involvement of the hand is exceedingly rare. A case of nodular fasciitis involving the dominant hand of a 38-year-old woman is reviewed, and its clinicopathologic features are presented. Because of its rapid growth and aggressive histologic appearance, nodular fasciitis can be mistaken for a soft tissue sarcoma, despite its benign clinical behavior. For this reason, aggressive surgical resection should be avoided.