Antigen processing in the endocytic compartment

Curr Opin Immunol. 2001 Feb;13(1):26-31. doi: 10.1016/s0952-7915(00)00177-1.


Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Endocytosis / immunology*
  • Endosomes / immunology*
  • Endosomes / metabolism*
  • Humans