The putative beta4-adrenergic receptor is a novel state of the beta1-adrenergic receptor

Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E199-202. doi: 10.1152/ajpendo.2001.280.2.E199.


The atypical beta3-adrenergic receptor (AR) agonist CGP-12177 has been used to define a novel atypical beta-AR subtype, the putative beta4-AR. Recent evaluation of recombinant beta-AR subtypes and beta-AR-deficient mice, however, has established the identity of the pharmacological beta4-AR as a novel state of the beta1-AR protein. The ability of aryloxypropanolamine ligands like CGP-12177 to independently interact with agonist and antagonist states of the beta1-AR has important implications regarding receptor classification and the potential development of tissue-specific beta-AR agonists.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Isoforms / physiology
  • Receptors, Adrenergic, beta / classification
  • Receptors, Adrenergic, beta / physiology*
  • Technology, Pharmaceutical


  • Protein Isoforms
  • Receptors, Adrenergic, beta