Genetics of surface antigen expression in Pneumocystis carinii

Infect Immun. 2001 Feb;69(2):627-39. doi: 10.1128/IAI.69.2.627-639.2001.

Abstract

This article reviews the molecular genetic data pertaining to the major surface glycoprotein (MSG) gene family of Pneumocystis carinii and its role in surface variation and compares this fungal system to antigenic variation systems in the protozoan Trypanosoma brucei and the bacteria Borrelia spp.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Borrelia / immunology
  • Chromosome Mapping
  • Fungal Proteins / genetics*
  • Fungal Proteins / physiology
  • Gene Expression Regulation, Fungal
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / physiology
  • Pneumocystis / genetics
  • Pneumocystis / immunology*
  • RNA, Messenger / analysis
  • Transcription, Genetic
  • Variant Surface Glycoproteins, Trypanosoma / genetics

Substances

  • Fungal Proteins
  • Membrane Glycoproteins
  • RNA, Messenger
  • Variant Surface Glycoproteins, Trypanosoma
  • GPA protein, Pneumocystis carinii sp.