The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions

J Bacteriol. 2001 Mar;183(5):1796-800. doi: 10.1128/JB.183.5.1796-1800.2001.

Abstract

miaA mutants, which contain A-37 instead of the ms(2)i(6)A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC-->TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases*
  • Alkyl and Aryl Transferases / genetics*
  • Alkyl and Aryl Transferases / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Base Pair Mismatch
  • DNA Repair
  • DNA-Binding Proteins*
  • Escherichia coli / classification*
  • Escherichia coli / genetics*
  • Escherichia coli Proteins*
  • MutS DNA Mismatch-Binding Protein
  • Mutation*
  • Phenotype
  • RNA, Transfer, His / genetics
  • RNA, Transfer, His / metabolism
  • Recombination, Genetic*
  • Sulfurtransferases / genetics
  • Sulfurtransferases / metabolism

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • RNA, Transfer, His
  • Alkyl and Aryl Transferases
  • adenylate isopentenyltransferase
  • MiaB protein, E coli
  • Sulfurtransferases
  • isopentenyl-adenosine i6a thiotransferase
  • Adenosine Triphosphatases
  • MutS DNA Mismatch-Binding Protein
  • MutS protein, E coli