Abstract
miaA mutants, which contain A-37 instead of the ms(2)i(6)A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC-->TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphatases*
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Alkyl and Aryl Transferases / genetics*
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Alkyl and Aryl Transferases / metabolism
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Base Pair Mismatch
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DNA Repair
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DNA-Binding Proteins*
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Escherichia coli / classification*
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Escherichia coli / genetics*
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Escherichia coli Proteins*
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MutS DNA Mismatch-Binding Protein
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Mutation*
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Phenotype
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RNA, Transfer, His / genetics
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RNA, Transfer, His / metabolism
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Recombination, Genetic*
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Sulfurtransferases / genetics
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Sulfurtransferases / metabolism
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Escherichia coli Proteins
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RNA, Transfer, His
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Alkyl and Aryl Transferases
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adenylate isopentenyltransferase
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MiaB protein, E coli
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Sulfurtransferases
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isopentenyl-adenosine i6a thiotransferase
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Adenosine Triphosphatases
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MutS DNA Mismatch-Binding Protein
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MutS protein, E coli