HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998

Neurology. 2001 Jan 23;56(2):257-60. doi: 10.1212/wnl.56.2.257.


This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / epidemiology*
  • Cohort Studies
  • Humans
  • Incidence
  • Lymphoma, AIDS-Related / epidemiology
  • Meningitis, Cryptococcal / epidemiology
  • Multicenter Studies as Topic
  • Toxoplasmosis, Cerebral / epidemiology
  • United States / epidemiology