Characterization of the mouse Cblc/Cbl3 gene

Biochem Biophys Res Commun. 2001 Jan 12;280(1):182-7. doi: 10.1006/bbrc.2000.4116.


The mouse Cblc/Cbl3 gene was cloned and characterized. It comprises 12 exons and encodes a putative protein of 496 amino acid residues which shares an overall 67% identity with its human ortholog; it also shares 70% of amino acid identity with mouse CBL over their conserved SH2 and Ring finger domains. Mouse Cblc mRNA is expressed in embryo and adult tissues and has a rather ubiquitous distribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Conserved Sequence
  • Exons
  • Gene Expression
  • Humans
  • Introns
  • Mice
  • Molecular Sequence Data
  • Oncogene Protein v-cbl
  • Organ Specificity
  • Proto-Oncogene Proteins c-cbl
  • Retroviridae Proteins, Oncogenic / chemistry
  • Retroviridae Proteins, Oncogenic / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Zinc Fingers*
  • src Homology Domains*


  • Oncogene Protein v-cbl
  • Retroviridae Proteins, Oncogenic
  • Proto-Oncogene Proteins c-cbl
  • Cblc protein, mouse