The UNC-104/KIF1 family of kinesins

Curr Opin Cell Biol. 2001 Feb;13(1):36-40. doi: 10.1016/s0955-0674(00)00171-x.


Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport, Active
  • Caenorhabditis elegans Proteins*
  • Humans
  • Kinesin / chemistry*
  • Kinesin / metabolism
  • Kinesin / physiology*
  • Molecular Motor Proteins / chemistry
  • Molecular Motor Proteins / metabolism
  • Molecular Motor Proteins / physiology
  • Nerve Tissue Proteins / chemistry*
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology*


  • Caenorhabditis elegans Proteins
  • KIF1A protein, human
  • Molecular Motor Proteins
  • Nerve Tissue Proteins
  • UNC-104 protein, C elegans
  • Kinesin